Studies about a protein that is involved in several neurodegenerative deseases
ICGEB, the International Center for Genetic Engineering and Biotechnology, based in Trieste, is announcing a new Arturo Falaschi conference, to be held in Trieste 6th to 8th September 2023, on the topic of “TDP-43 function and dysfunction in disease”.
TDP-43 is a human protein that is thought to be involved in several diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and also Alzheimer’s Disease and Parkinson’s Disease. As a result, there is a growing interest in developing new approaches to understand the consequences of TDP-43 mislocalization and aggregation in disease.
Normal behavior in question
Even so, the precise function of TDP-43 in normal cells remains unclear, as are the initial events driving TDP-43 mislocalization and aggregation in disease, and the impact of TDP-43 pathology on neuronal integrity.
The meeting organized in Trieste represents an ideal opportunity for discussing ongoing epidemiological, clinical, pathological, neuroimaging and genetic investigations of this protein. This venue will also serve as a platform for presenting and discussing the latest TDP-43 based therapeutic strategies that are being developed and tested in disease models.
The Arturo Falaschi Conference series, featuring major meetings in the fields of Life Sciences was launched in 2012, spanning topics in Cardiac and Vascular Regeneration, DNA Tumour Viruses, DNA Replication and Genome Maintenance, and Atypical dementias. In October, in Cape Town, another conference in the series will be held on the topic: “Advances in prostate and cervical cancer research“.